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Cialis 5-mg daily dosing is the only PDE5 inhibitor dose approved for treating an enlarged prostate; improving ED symptoms is an added benefit of the daily dose. Talk with your doctor about other drug options that may work for you. You should not need a new prescription for this medication to be refilled.
How to take sildenafil
The pharmacokinetics of sildenafil are dose-proportional over the recommended dose range. It is eliminated predominantly by hepatic metabolism (mainly CYP3A4) and is converted to an active metabolite with properties similar to the parent, sildenafil. Both sildenafil and the metabolite have terminal half lives of about 4 hours.
2 Hypersensitivity Reactions
If you're also on a nitrate drug for heart problems or buy xanax without prescrition if you've had a heart attack in the last six months, Sildenafil may not be suitable for you. Sildenafil should not be used in patients with certain hereditary eye conditions and it can interact with some medicines to cause serious heart issues. Viagra® (sildenafil citrate) is prescription medicine used to treat erectile dysfunction (ED).
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In healthy male volunteers, there was no evidence of a clinically significant effect of azithromycin (500 mg daily for 3 days) on the systemic exposure of sildenafil or its major circulating metabolite. Single oral doses of sildenafil up to 100 mg produced no clinically relevant changes in the ECGs of normal male volunteers. Twenty subjects received VIAGRA 50 mg, but only 19 subjects received matching placebo. One patient discontinued the study prematurely due to an adverse event of hypotension following dosing with VIAGRA 50 mg. This patient had been taking minoxidil, a potent vasodilator, during the study.
In the event of an erection that persists longer than 4hours, the patient should seek immediate medical assistance. If priapism is nottreated immediately, penile tissue damage and permanent loss of potency mayresult [see WARNINGS AND PRECAUTIONS]. Physicians should advisepatients of the potential for VIAGRA to augment the blood pressure loweringeffect of alpha-blockers and anti-hypertensive medications. Concomitantadministration of VIAGRA and an alpha-blocker may lead to symptomatichypotension in some patients.
Sildenafil at recommended doses has no effect in the absence of sexual stimulation. Physicians should advisepatients to stop taking PDE5 inhibitors, including VIAGRA, and seek promptmedical attention in the event of sudden decrease or loss of hearing. Theseevents, which may be accompanied by tinnitus and dizziness, have been reportedin temporal association to the intake of PDE5 inhibitors, including VIAGRA. Itis not possible to determine whether these events are related directly to theuse of PDE5 inhibitors or to other factors [see WARNINGS ANDPRECAUTIONS and ADVERSE REACTIONS]. Caution is advised when PDE5 inhibitors areco-administered with alpha-blockers. PDE5 inhibitors, including VIAGRA, andalpha-adrenergic blocking agents are both vasodilators with blood pressurelowering effects.
When VIAGRA 100 mg was co-administered with amlodipine (5 mg or 10 mg) to hypertensive patients, the mean additional reduction on supine blood pressure was 8 mmHg systolic and 7 mmHg diastolic [see WARNINGS AND PRECAUTIONS, CLINICAL PHARMACOLOGY]. The following adverse reactions have been identified during post approval use of VIAGRA. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.